Pharmaceutical evaluation of cefuroxime axetil tablets available in drug market of Pakistan

The stability of Cefuroxime axetil in tablets.

The stability of cefuroxime axetil in BIORACEF tablets was studied by means of long term (298 K/60% RH), intermediate (303 K/65% RH), accelerated (313 K/75% RH) and stress stability tests. Changes in the concentration of cefuroxime axetil diastereoisomers A and B and their total was determined using the RP-HPLC method, as described in a monograph of Cefuroxime axetil tablets in the British Phar...

Validated Spectrophotometric Methods for the Determination of Cefuroxime Axetil in Bulk Drug and Tablets

Two simple spectrophotometric methods have been developed for the determination of Cefuroxime Axetil in bulk drug and its tablet formulation. Method I is a simple UV spectrophotometric method. In this method the simple UV spectrum of Cefuroxime Axetil in 0.1 N HCl was obtained which exhibits absorption maxima (λ max) at 281 nm. Calibration curve was prepared by plotting the absorbance vs. conce...

CODEN : IJPNL 6 Formulation and evaluation of bilayered floating tablets of cefuroxime axetil

Study aims to design a Gastro retentive Drug Delivery System of Cefuroxime axetil (CA). CA is a broad spectrum beta lactam type of antibiotic. More specifically, it is a second-generation cephalosporin. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of ant...

investigation of pharmaceutical properties of cefuroxime axetil oral suspension

Evaluation of the use of cefuroxime and cefuroxime axetil in an intravenous-oral stepdown program.

OBJECTIVE To characterize cefuroxime and cefuroxime axetil use under the influence of a parenteral-to-oral (iv-po) stepdown program. DESIGN Open single-center retrospective review. SETTING Tertiary care teaching and referral Canadian hospital with 1100 beds. PATIENTS A random sample of 78 patients receiving cefuroxime was compared with a random sample of 50 patients receiving iv-po cefuro...